Endogenous Tumor Necrosis Factor Acts as a Cytoprotective Factor.
نویسندگان
چکیده
منابع مشابه
The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart.
BACKGROUND Activation of both type 1 and type 2 tumor necrosis factor (TNF) receptors (TNFR1 and TNFR2) confers cytoprotection in cardiac myocytes. Noting that the scaffolding protein TNF receptor-associated factor 2 (TRAF2) is common to both TNF receptors, we hypothesized that the cytoprotective responses of TNF were mediated through TRAF2. METHODS AND RESULTS Mice with cardiac-restricted ov...
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Based on the finding that expression of endogenous tumor necrosis factor (TNF) which is not detected in TNF-susceptible cells was observed in TNF-resistant cells, the assumption was made that endogenous TNF may be a protective protein against the cytotoxic activity of TNF. In order to confirm this possibility, we investigated the relationship between expression of endogenous TNF and TNF suscept...
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ژورنال
عنوان ژورنال: Thermal Medicine(Japanese Journal of Hyperthermic Oncology)
سال: 1998
ISSN: 0911-2529,1881-9516
DOI: 10.3191/thermalmedicine.14.99